Adrenaline and Guanethidine Combinations in Glaucoma
نویسنده
چکیده
Professor Drance commented that the use of a combination of adrenaline and guanethidine might be of great importance in reducing the side-effects due to adrenaline alone. He noted that the results from his own series were different from those reported by Dr. Paterson and Mr. Miller. In Professor Drance's study the patients had been pretreated with guanethidine only for 3 days and were then studied with the instillation of a single drop of adrenaline. This was a single-dose response study, whereas in Dr. Paterson's study the guanethidine was used for prolonged periods so that the sympathetic denervation had occurred which was obviously not complete in his own shorter studies. Punctate epitheliopathy did occur on occasion with guanethidine therapy but was much more common when the IO per cent. solution was used rather than the 5 per cent. or evern 2 per cent. solution now in common use. The epitheliopathy always disappears if the drugs are discontinued.
منابع مشابه
A double blind comparison of guanethidine-and-adrenaline drops with 1% adrenaline alone in chronic simple glaucoma.
We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10.67 mmHg, and with adrenaline 1% 6.31 mmHg, 24 hours after the commenceme...
متن کاملadrenaline alone in chronic simple glaucoma
We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3 % and adrenaline 0 5 % with that of adrenaline 1 % alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10-67 mmHg, and with adrenaline 1% 6-31 mmHg, 24 hours after the commenc...
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A trial of a mixture of guanethidine 5% and adrenaline 0.5% (Ganda 5.05) and of guanethidine 3% and adrenaline 0.5% (Ganda 3.05) was conducted on 90 eyes in 53 patients with open-angle glaucoma or ocular hypertension. The cases fell into 5 groups: untreated cases, cases on pilocarpine 1%, on pilocarpine 2%, on pilocarpine 2 to 4% and adrenaline 1%, and on separate guanethidine 5% and adrenaline...
متن کاملControl of glaucoma by reduced dosage guanethidine-adrenaline formulation.
The effect of formulations of guanethidine and adrenaline of different composition has been tested in rabbits and in patients with glaucoma. The concentrations of guanethidine and adrenaline used for the rabbits were 5.0% and 1.0%; 2.5% and 0.5%; 1.0% and 0.2%; 0.5% and 0.1%. All except the lowest combination were equally effective in the magnitude of the decrease in intraocular pressure brough...
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تاریخ انتشار 2005